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haha777 ink Jonathan Knowles My last update on ImmunityBio, Inc. ( NASDAQ: IBRX ) followed the FDA-approval of Anktiva (nogapendekin alfa inbakicept) for the treatment of BCG-unresponsive non-muscle invasive bladder cancer (NMIBC). I conducted a discounted cash flow analysis that valued Anktiva at $2.3 billion (net present value) based on a 50% market share Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. This article is intended to provide informational content and should not be viewed as an exhaustive analysis of the featured company. It should not be interpreted as personalized investment advice with regard to "Buy/Sell/Hold/Short/Long" recommendations. The predictions and opinions presented are based on the author's analysis and reflect a probabilistic approach, not absolute certainty. Efforts have been made to ensure the information's accuracy, but inadvertent errors may occur. Readers are advised to independently verify the information and conduct their own research. Investing in stocks involves inherent volatility, risk, and speculative elements. Before making any investment decisions, it is crucial for readers to conduct thorough research and assess their financial circumstances. The author is not liable for any financial losses incurred as a result of using or relying on the content of this article. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.

Charleston Southern’s disappointing football season ended on Saturday as the Bucs lost at Florida State, 41-7. CSU finishes the season with a 1-11 record, losing their final 10 games after a win over Furman in week two of the regular season. The Bucs hung tough early, trailing only 3-0 with five minutes left in the first half. The Seminoles, however, scored two touchdowns in the final 4:05 of the second quarter to take a 17-0 lead at the break. Charleston Southern wraps up season at Florida State “Really proud of the way our guys competed. The moment was not too big for them,” CSU coach Gabe Giardina said. “I thought we showed the right kind of character and I was impressed with how we competed. “It’s been a season of near misses, losing five games by five points or less, but this team has been a joy to coach because of how they came to work every day.” CSU’s lone touchdown came with 57 seconds left in the game when Kaleb Jackson and tight end Landon Sauers combined on a seven-yard pass. CSU loses in overtime to Eastern Illinois; fall to 1-10 Jackson finished the game with 221 passing yards, completing 22-of-32 passes. Chris Rhone had 60 yards on three receptions. The Bucs totaled 275 yards in offense for the game as the Seminoles limited CSU to only 57 yards rushing. Davion Williams led CSU’s defensive effort with eight tackles, a sack, and two tackles for loss. No-surrender Buccaneers face final 2 games on road “We gave up some big plays in the second half but I thought we competed at a high level defensively in the first half,” Giardina said. “Our guys fought their butts off, just like they have all season.”

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Gamers can often be difficult people to shop for, especially those who curate the vibe of their setup as much as their gaming library. But cozy gamers can be the most fun to shop for, since you can think outside the box and surprise them with gifts they’d never think to get for themselves. As lovers of cozy games and gaming accessories , our expert staff has rounded up 10 great gift ideas to give the teen, college student, or cozy gamer of any age in your life. And, since we know the holidays are coming up quickly, many of them are available for speedy delivery with an Amazon Prime subscription (which comes with six months free if you’re between 18-24 and sign up before Dec. 20). Bulbasaur planter Every desk could use a bit more Bulbasaur. The cute grass-type Pokémon makes a perfect home for a small succulent that will add a pop of color to anyone’s gaming space. This tiny planter includes a drainage hole, so after watering, be sure to let it drain fully to ensure your gaming gear stays dry. Turtle artisan keycap Getting new keycaps is a simple change that can completely change the vibe of a gaming setup. You could buy someone a whole new set, but it’s more personal to find the exact keycap to fit the recipient’s personality and personal style. Amazon stocks several options, but we’re partial to this colorful turtle keycap (perfect to use for the “T” key). Skull & Co. thumbstick grips Many of our recommendations are about setting the right atmosphere, but being comfortable is just as important. If you notice that your loved one’s analog sticks are worse for wear, or if they complain about thumb pain while gaming, Skull & Co.’s stick grips are a good solution for bringing an extra level of comfort to controllers. Each set comes with options for adding grippier texture to slippery sticks, or adding some height to ones that feel too short. Queen Rose gaming pillow A gaming pillow is a great gift for anyone who plays on a handheld device or with a controller. Queen Rose’s wrap-around lap pillow comes in a variety of color options and offers arm, elbow, and back support while your cozy gamer invests long hours into their favorite games. Govee TV Backlight 3 Lite Finding the right lighting is absolutely key to creating the perfect ambience, and Govee’s TV Backlite 3 takes it to the next level by matching the visuals of whichever cozy game is being played. These lights create the ultimate immersive gaming experience by mimicking the colors on the TV and adding a matching splash to the wall behind. If you’re shopping for a PC gamer , Govee makes a similar model for monitors. Livabliss Hapsburg shag rug Sometimes, the best addition to a gaming space is something that can just tie the room together. So don’t underestimate the comfort-enhancing powers of a simple rug, like this plush shag one that will add luxurious texture to any setup. Whether it goes under their couch, computer desk, or wherever the recipient likes to sit while unwinding, the coziness of the space will be improved immensely. Llama hooded blanket Rather than tucking in with a blanket — which can render you a bit immobile — a hooded wrap has all the benefits of a blanket with the bonus of being cuter and easier to game in. We love this one that looks like a cuddly llama, but Amazon also has hooded blankets for those who’d prefer to be a sloth or axolotl . Or, if you think your loved one wants pockets and a more jacket-like fit for their cozy gaming uniform, UnHide’s Shleepy Robe will make for a great gift. Bamboo food trays (set of 2) Despite our best intentions, we can all be a little messy. If the person you’re buying gifts for is known for enjoying a snack or drink while they play games, do them (and their precious gadgets) a favor and surprise them with a cute bamboo food tray. It’s where all of the crumbs and inevitable spills can safely exist instead of falling on their desk or floor, where they might be forgotten. Logitech cloud wrist rest Cozy games aren’t so cozy if you aren’t comfortable. A good wrist rest, like this adorable (and TikTok-approved) cloud one from Logitech, not only will make playing PC games more enjoyable, but it’s a great way to lean into a room’s aesthetic — or serve as the launching point for creating one. This cute, seemingly minor upgrade is a gift that shows you’re looking out for your loved one’s well-being and honoring their taste in design. Gastly 3D-printed humidifier For all the good they do, most humidifiers are eyesores that stick out due to their bland or outright ugly design. Well, in the case of this humidifier, sticking out is a good thing, as it turns the typically boring gadget into a centerpiece any Pokémon fan would love. Designed to look like Gastly is popping out of a Poké Ball, this humidifier’s purple light shines through the water vapor, making it look like Gastly has come to life. Shopkeeper Polygon’s handpicked deals on games, movies, books, and more. Gaming Gift Guide Hardware Shopping Style

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Sun Life Financial Inc. stock falls Wednesday, underperforms marketPlans Required to Cover Treatment for SOD1-ALS ARLINGTON, Va. , Dec. 11, 2024 /PRNewswire/ -- The Centers for Medicare & Medicaid Services (CMS) has announced a first-of-its-kind directive requiring Medicare Advantage plans to approve coverage for Qalsody, a treatment for people living with genetic SOD1-ALS. This decision reflects the ALS Association's commitment to ensuring that people living with ALS have access to promising ALS treatments without delay. "This is a victory for the entire ALS community," said Calaneet Balas, president and CEO of the ALS Association. "It's critical that FDA-approved treatments are made accessible rather than being labeled as 'experimental.' We are grateful to everyone in our community who helped make this day happen." Balas added: "We hope this sends a message to the entire rare disease community and pharmaceutical industry that new treatments can be developed and made accessible to those who will benefit from them. We need to ensure more ALS treatments are developed and approved that will help everyone living with ALS." The ALS Association played a key role in the historic CMS directive by participating and advocating for the research, approval, and accessibility of Qalsody for people living with ALS. In 2004, the ALS Association was the first to fund research into ALS-specific antisense oligonucleotide (ASO) technology, investing over $1.3 million in groundbreaking studies that laid the foundation for the development of Qalsody. This early commitment supported preclinical studies, safety trials, and the first-in-human phase 1 trial, which established SOD1 as a viable therapeutic target. In 2023, Qalsody became the first gene-based therapy approved for ALS , thanks in part to the ALS Association's efforts, including a united push from the ALS community for FDA accelerated approval. This new CMS directive provides precedent for state regulators to issue similar actions for other private insurers. According to the Valor study published in 2022 , Qalsody, which was developed specifically to target the RNA produced by mutated SOD1 genes, has demonstrated significant promise in clinical trials and real-world studies. In the phase 3 VALOR trial, Qalsody reduced levels of mutated SOD1 proteins in cerebral spinal fluid by 35% within eight weeks and decreased bloodstream levels of neurofilament light chain (NfL)—a key biomarker of neurodegeneration—by 50% within 12-16 weeks. These biological changes translated into measurable clinical benefits, including slower disease progression, improved respiratory function, and enhanced quality of life after 52 weeks of treatment. Real-world data has since validated these findings, with some patients stabilizing or even experiencing improvements in motor function and quality of life. When insurance companies began denying access to Qalsody, labeling it as "experimental," the ALS Association took decisive action, working directly with CMS to launch an investigation into these unjust denials. By presenting evidence of widespread insurance rejections and demonstrating the critical need for immediate intervention. In addition to working with CMS, the ALS Association actively engaged policymakers, held strategic meetings with state and federal legislators, and served as a staunch advocate for patients, ensuring their voices were heard and their rights to life-changing treatment were upheld. The ALS Association urges anyone previously denied Qalsody by their Medicare Advantage plan to contact their ALS specialist immediately to begin the process of securing access to this critical treatment. For more information on the CMS directive visit als.org About the ALS Association The ALS Association is the largest ALS organization in the world. The ALS Association funds global research collaborations, assists people with ALS and their families through its nationwide network of care and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association is working to make ALS a livable disease while urgently searching for new treatments and a cure. For more information about the ALS Association, visit our website at www.als.org . About ALS Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Over the course of the disease, people lose the ability to move, to speak, and eventually, to breathe. The disease is always fatal, usually within five years of diagnosis. Few treatment options exist, resulting in a high unmet need for new therapies to address functional deficits and disease progression. View original content to download multimedia: https://www.prnewswire.com/news-releases/groundbreaking-directive-ensures-als-patients-on-medicare-advantage-gain-access-to-qalsody-302329525.html SOURCE The ALS AssociationAn Ohio politician has seen enough flag planting by visiting sports teams. Republican state Rep. Josh Williams said Wednesday on social media he’s introducing a bill to make flag planting in sports a felony in the state. His proposal comes after the Nov. 30 fight at the Michigan-Ohio State rivalry football game when the Wolverines beat the Buckeyes 13-10 and then attempted to plant their flag at midfield. A fight ensued and police had to use pepper spray to disperse the players. Similar flag-planting scuffles broke out across college football on that rivalry weekend. Williams is calling it the O.H.I.O Sportsmanship Act. “Behavior that incites violent brawls and puts our law enforcement officers in danger has no place on the football field,” Williams said. Former Oklahoma quarterback Baker Mayfield famously planted a flag in the middle of the field at Ohio State after the Sooners beat the Buckeyes in 2017. Mayfield, who now plays for the NFL’s Tampa Bay Buccaneers, said he doesn’t think flag planting is a big deal. “I’ll say this: OU-Texas does it every time they play,” Mayfield said on Dec. 1. “It’s not anything special. You take your ‘L’ and you move on. I’ll leave it at that.” ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football

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TTM Technologies, Inc. Introduces Innovative Radio Frequency Components for Telecom Band n104 to Enhance 5.5G ApplicationsUber Technologies Inc. stock falls Wednesday, underperforms marketAI a productivity boost to banks but making money from it is a challenge

Baltimore (7-4) at Los Angeles Chargers (7-3) Monday, 8:15 p.m. EST, ESPN/ABC BetMGM NFL odds: Ravens by 3. Against the spread: Ravens 5-5-1; Chargers 7-3. Series record: Ravens lead 9-5. Last meeting: Ravens beat Chargers 20-10 in Inglewood, Calif., on Nov. 26, 2023. Last week: Ravens lost to Pittsburgh 18-16; Chargers beat Cincinnati 34-27. Ravens offense: overall (1), rush (2), pass (3), scoring (2). Ravens defense: overall (3), rush (26), pass (2), scoring (23). Chargers offense: overall (18), rush (12), pass (19), scoring (18). Chargers defense: overall (11), rush (11), pass (12), scoring (1). Turnover differential: Ravens plus-2; Chargers plus-8. K Justin Tucker missed two field goals last week and is under pressure after spending most of his career beyond reproach. He’s missed six field goals on the season and is 4 for 12 from 50-plus yards since the start of last season. Story continues below video WR Ladd McConkey had a career-high 123 yards on six receptions against Cincinnati. The rookie came up with clutch catches of 28 and 27 yards to set up the game-winning touchdown. Chargers RB J.K. Dobbins vs. Ravens’ run defense. Dobbins showed promise during his time in Baltimore, but he never was able to live up to that potential because of injuries. Now in Los Angeles on a one-year “prove it” contract, Dobbins has nearly matched his most productive season as a professional with 726 yards and eight touchdowns in 10 games. After seeing Pittsburgh run the ball 34 times last week, the Chargers will be glad to copy that bruising approach with Dobbins. The Ravens are allowing 77.5 rushing yards per game, but even the sturdiest defense can buckle against that volume of work, so getting off the field will be critical. Baltimore’s defense has one significant injury concern, with LB Roquan Smith (hamstring) questionable to go this week after he was hurt against the Steelers. The good news is S Kyle Hamilton does not have an injury designation. He has been nursing an ankle problem, although he played against Pittsburgh. ... Chargers OLB Khalil Mack (groin) is questionable after the veteran pass rusher didn’t play against Cincinnati. ... McConkey is also questionable because of a shoulder injury. The Ravens have won four straight over the Chargers in the regular season, but Los Angeles did earn a 23-17 AFC wild-card round upset in January 2019. ... Baltimore cruised to a 34-6 win over the Chargers in its first visit to SoFi Stadium on Oct. 17, 2021. Ravens RB Derrick Henry leads the NFL with 1,185 yards rushing and 15 total TDs (13 rushing and two receiving). He’s also run for a league-high 52 first downs. ... Henry is one rushing TD shy of the Ravens’ single-season record, set by Jamal Lewis in 2003. ... Baltimore QB Lamar Jackson is 6-2 on “Monday Night Football” with 20 TD passes and no interceptions. ... Henry is one of four players in the Super Bowl era to score a TD in each of the first 11 games of a season. The others are O.J. Simpson (1975), John Riggins (1983) and Jerry Rice (1987). ... The Ravens have scored touchdowns on a league-best 77.8% of their red zone trips. ... Jackson needs 124 yards passing and 16 yards rushing for a second consecutive season with 3,000 passing and 600 rushing. Since the AFL-NFL merger, only Randall Cunningham (1988-1990), Cam Newton (2011-12), Josh Allen (2021-22) and Jalen Hurts (2021-23) have accomplished that feat. ... Dobbins ran for two touchdowns against Cincinnati, giving him multiple scores in two of his past three games. He did it twice in 24 games as a Raven. ... OLB Tuli Tuipulotu had 1 1/2 sacks of Bengals QB Joe Burrow, his third straight game with more than one. All seven of Tuipulotu’s sacks this season have come in the past four games, and six of his eight tackles for loss have come in that span. ... The Chargers allowed a season-worst 27 points to Cincinnati after holding each of their previous nine opponents to 20 points or fewer. ... QB Justin Herbert has thrown one interception in 277 attempts this season. That lone pick came in Week 2 at Carolina. ... The Chargers lost their fifth turnover of the season when Herbert fumbled to start the fourth quarter. It was their first turnover at home. ... Los Angeles does not have a takeaway in its past two games. Herbert has heated up after a slow start in terms of fantasy production, having thrown for multiple touchdowns in three of his past four games. He is likely to keep that success going this week. Baltimore has allowed 22 scores through the air, which is tied with Houston for second most in the league, and Herbert should have plenty of chances to add to that total in what could be another high-scoring matchup. AP NFL: https://apnews.com/hub/NFL

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