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p777 slot Surprising Kasper Schmeichel skill that's made Celtic a Champions League force again

No. 25 Illinois gets 40-yard TD with 4 seconds left for 38–31 win over RutgersAs the two teams prepare to face off once again, both sides will be aiming for a positive result. Real Madrid will be looking to continue their winning streak against Atalanta and secure a vital three points in the group stage. On the other hand, Atalanta will be seeking to break their losing streak against Real Madrid and make a statement in the highly competitive Champions League.

Veteran actress Stefanie Powers (“Hart to Hart”) chatted about the William Holden Wildlife Foundation and being a part of the “Vision For The Future” book. First Lady Eleanor Roosevelt once said: “The future belongs to those who believe in the beauty of their dreams.” A woman that embodies this wise quote is Stefanie Powers. Powers spoke about the 45th anniversary of “Hart to Hart,” where she starred opposite the iconic Robert Wagne r. “The 45 th anniversary flew by. Time flies, doesn’t it? When you have these wonderful memories, they all seem as if they were yesterday,” she said. “I am in touch with Robert Wagner, he is a great man, and we celebrated his 94 th birthday together, and we have every reason to believe that we will be celebrating his 95 th birthday in February, and he will still have his twinkle,” she elaborated. Powers was drawn to her character, Jennifer in “Hart to Hart” for several reasons. “I love the way in which Tom Mankiewicz re-wrote the original idea that was called ‘Double Twist’ and he made it ‘Hart to Hart.’ He created the Jonathan and Jennifer rapport based most generally on the movies were so famous ‘The Thin Man’ movies with Myrna Loy and William Powell,” she explained. “There was a certain rapport between the two characters, and we really were a shadow of ‘The Thin Man,’ and it was that rapport was wonderful fantasy romp between these wonderful characters, who didn’t have to qualify or explain their relationship because it wasn’t that kind of show. It was this stylish couple who solved crimes,” she elaborated. For her powerful performances as Jennifer in “Hart to Hart,” she earned two Emmy nominations and five Golden Globe nominations. “It was very nice to be acknowledged, and I was appreciative of that,” she said. “I am less interested in the awards because what am I going to do? Put them on a shelf and let them collect dust. I am more interested in the work, most particularly in the area of wildlife conversation and education.” As much a part of her life as her career in entertainment, is her devotion to animal preservation and protection, which at times becomes more of a vocation than an avocation. The William Holden Wildlife Foundation Education Center offers visiting students the distinct opportunity to experience the outdoors in a rare communication with nature often unavailable to them in their own environment. It is essential to build respect and appreciation for both flora and fauna and the understanding of their delicate balance. Nature is a renewable resource, but only if we assume responsibility for its protection. Powers revealed that she is the “founder and president of the William Holden Wildlife Foundation,” which was established to continue and to further her long-time partner’s conservation work in East Africa after his death. “I created this foundation after Bill’s death in 1981,” she said. “I thought this would be an appropriate living memorial to Bill because education is a living, breathing thing, and it is always changing and always growing.” Powers founded this 501(c)(3) public charity in an effort to build and endow the education center Bill had imagined whose mission statement is “Wildlife conservation through education and alternatives to habitat destruction.” “The objective of this was to influence and educate local people to understand the meaning of biodiversity, and how it affected them,” she said. “In the first part of the mission statement, our education center services about 11,000 students a year,” Powers noted. “We also have an outreach program that goes into seven very rural and mostly impoverished areas, and in that outreach program, we serve approximately between 6,000 and 7,000 people, so we are busy.” “The second half of the mission statement has to do with restoring and regenerating the habitat that we’ve overexploited. It begins with a program that we have ongoing with seven projects to reestablish biodiversity in soils that have been burnt out through over-chemicalization,” she elaborated. “We have a combination of soil regeneration with technique that are a combination of regenerative farming and those methods are inclusive,” she added. Powers will be included in a new book, “Vision For The Future: Capturing Inspiring Stories from Leaders and Changemakers,” along with 25 other individuals who are focused on making the world a better place. Each chapter will highlight the objective, impact, partnerships, investments, and personal stories behind these groundbreaking efforts. “It is a great honor to be included with such remarkable people,” Powers said. “There are 25 of us being highlighted for the work that we do in different fields.” “It is intended to not only highlight our work but to encourage others to either participate on their own and see that they too can do something, or they might join us in any one of the efforts that are represented by the people that are being highlighted. It is an honor to be included among this wonderful company,” she elaborated. Speaking of books, Powers opened up about her own memoir “One from the Hart.” “My book has been out for quite some years, so it’s not new, but it is available. It was something that I needed to write after the death of my mother and my first diagnosis with cancer. I felt that I needed the catharsis,” she said. “People are still asking me to write some more because there are not very many of us left who actually experienced that extraordinary period of time. When I was approached by Simon & Schuster to write this autobiography, it was the right time for me,” she added. “One from the Hart” is available on Amazon by clicking here . Powers was honored for her efforts with the William Holden Wildlife Foundation, at a luncheon held at the United Nations for the following listed reasons. She was recognized for inspiring others to make a large-scale impact on society through the William Holden Wildlife Foundation, for leaving a legacy, and for reaching a wide audience, where she is able to deliver her message to a worldwide audience. Regarding the key to longevity in the entertainment business, she said, “It is about being lucky.” On the title of the current chapter of her life, Powers said, “Ongoing.” For young and aspiring actors, Powers encouraged them to “never turn down a job,” and rightfully so. On being a part of the digital age, Powers said, “I think it’s’ a work in progress. I don’t think we’ve clearly defined yet what we are going to be with all of this technology.” “Let’s remember that the iPhone is less than 20 years old, so let’s not forget the passage of time. I think all the lessons for the future are in the past. I am a huge advocate for the study of history,” she acknowledged. Powers is a firm believer of the following quote by the late but great Winston Churchill: “”Those who fail to learn from history are doomed to repeat it.” On the best advice she has ever been given, she responded, “I have been given so much good advice by so many extraordinary people, I hardly know where to start.” “I am grateful for every piece of advice I have received from people who had the knowledge, and I did not,” she noted. “I am humbled by the fact that they were generous enough to give me some advice. There are too many to mention. I am privileged to have met or known some extraordinary people over my lifetime,” she acknowledged. Regarding her definition of the word success, Powers said, “Success means an avenue toward accessibility.” “With success comes a great privilege to be able to have access to all sort of things, and to be able to make people aware of the things that you are passionate about, and hopefully, either encourage them to participate in the William Holden Wildlife Foundation, or in something similar that they feel strongly about,” she elaborated. For her fans, Power remarked, “I wouldn’t be anywhere without my fans. I appreciate every single one of them.” “As sometimes happens with enthusiastic fans, they would want to give me presents, and I would tell them ‘Please don’t spend your money on presents, and what I would more appreciate is a donation to the William Holden Wildlife Foundation,” she explained. “It is from that basis of those extraordinary fans over the years, who have stayed with me all that time, and who have formed one of the most supportive financial bases of our success,” she expressed. “I am overwhelmed and overjoyed with the fans’ generosities, and I love them all. I couldn’t be more thrilled,” she concluded. To learn more about the William Holden Wildlife Foundation, check out its official website . Markos Papadatos is Digital Journal's Editor-at-Large for Music News.Papadatos is a Greek-American journalist and educator that has authored over 22,000 original articles over the past 18 years. He has interviewed some of the biggest names in music, entertainment, lifestyle, magic, and sports. He is a 16-time "Best of Long Island" winner, where for three consecutive years (2020, 2021, and 2022), he was honored as the "Best Long Island Personality" in Arts & Entertainment, an honor that has gone to Billy Joel six times.As New York City prosecutors worked Thursday to bring murder charges against Luigi Mangione in the brazen killing of UnitedHealthcare CEO Brian Thompson , supporters of the suspect are donating tens of thousands of dollars for a defense fund established for him, leaving law enforcement officials worried Mangione is being turned into a martyr. Several online defense funds have been created for Mangione by anonymous people, including one on the crowdfunding website GiveSendGo that as of Thursday afternoon had raised over $50,000. The GiveSendGo defense fund for the 26-year-old Mangione was established by an anonymous group calling itself "The December 4th Legal Committee," apparently in reference to the day Mangione allegedly ambushed and gunned down Thompson in Midtown Manhattan as the executive walked to his company's shareholders conference at the New York Hilton hotel. "We are not here to celebrate violence, but we do believe in the constitutional right to fair legal representation," the anonymous group said in a statement. The crowdfunding campaign prompted donations from more than 1,500 anonymous donors across the country, many of them leaving messages of support for Mangione, including one person who called themselves "A frustrated citizen" and thanked Mangione for "sparking the awareness and thought across this sleeping nation." The GiveSendGo fund for Mangione appeared to be briefly taken down before it was restored on Thursday. GiveSendGo did not immediately respond to ABC News' requests for comment. Other crowdfunding sites such as GoFundMe have also taken down campaigns soliciting donations for Mangione's defense. "GoFundMe's Terms of Service prohibit fundraisers for the legal defense of violent crimes," the crowdfunding website said in a statement. "The fundraisers have been removed from our platform and all donors have been refunded." Amazon and Etsy have removed from their websites merchandise featuring Mangione, including T-shirts and tote bags reading "Free Luigi" and the phrase "Deny, Defend, Depose," words police said were etched in the shell casings discovered at the scene of Thompson's homicide. "Celebrating this conduct is abhorrent to me. It's deeply disturbing," Manhattan District Attorney Alvin Bragg told ABC News senior investigative reporter Aaron Katersky in an interview Wednesday night. "And what I would say to members of the public, people who as you described are celebrating this and maybe contemplating other action, that we will be vigilant and we will hold people accountable. We are at the ready." Prosecutors at the Manhattan district attorney's office have begun presenting evidence to a grand jury as they work to try to secure an indictment against Mangione, sources told ABC News on Thursday. Mangione's attorney, Thomas Dickey of Altoona, Pennsylvania, where Mangione was arrested Monday following a five-day manhunt, said his client is presumed innocent and will plead not guilty to any charges filed against him. Mangione is contesting extradition to New York. Asked about people contributing to Mangione defense funds that have popped up, Dickey said, "People are entitled to their opinion and, like I said, if you're an American and you believe in the American criminal justice system, you have to presume him to be innocent and none of us would want anything other than that if that were us in their shoes. So, I'm glad he had some support." But law enforcement officials have expressed concern that Mangione is being turned into a martyr. Someone this week pasted "wanted posters" outside the New York Stock Exchange naming other executives. A bulletin released Wednesday by the Delaware Valley Intelligence Center, a multi-agency law enforcement intelligence-sharing network based in Philadelphia, included a photo of a banner hanging from an overpass reading, "Deny, Defend, Depose." "Many social media users have outright advocated for the continued killings of CEOs with some aiming to spread fear by posting 'hit lists,'" the bulletin, obtained by ABC News, reads. Meanwhile, New York Police Department investigators continue to build a murder case against Mangione, who is being held in Pennsylvania on charges stemming from his arrest there, including illegal possession of ghost gun and fraudulent identification. Mangione has pleaded not guilty to the charges in Pennsylvania. On Wednesday, NYPD Commissioner Jessica Tisch said that the three shell casings recovered at the scene of Thompson's shooting matched the gun found in Mangione possession when he was arrested. She also confirmed that Mangione's fingerprints were recovered from a water bottle and the wrapper of a granola bar found near the crime scene.Netflix launches Squid Game experience in Sydney ahead of season two of popular show

Real Madrid, one of the most successful football clubs in the world, is no stranger to busy schedules. Competing in multiple domestic and international competitions means that the players have to be ready to give their all in each game. Ancelotti acknowledged that it is indeed challenging to avoid injuries when the pressure is high and the matches come thick and fast. However, he also highlighted the need for proactive measures to ensure the team's fitness and well-being.Pitt QB Eli Holstein carted off with leg injuryA couple of squads looking to climb closer to .500 meet up on Thursday, Nov. 21 with the Charlotte Hornets hosting the Detroit Pistons at Spectrum Center in Charlotte, N.C. The game is scheduled to start at 7 p.m. EST and will be broadcast on NBA TV, FanDuel Sports Network Detroit and FanDuel Sports Network Southeast . Fans looking to watch this NBA game can do so for free by using FuboTV and DirecTV Stream, which both offer a free trial or with SlingTV, which doesn’t offer a free trial but has promotional offers available . The Hornets are 5-9 and on a two-game losing streak. The most recent loss came on Tuesday in an NBA Cup game against the Brooklyn Nets, 116-115. The Pistons also come into this contest following a loss, a matchup with the Chicago Bulls on Monday. The squad is 7-9 on the season after starting 0-4. Who: Detroit Pistons vs. Charlotte Hornets When: Thursday, Nov. 21 at 7 p.m. EST Where: Spectrum Center in Charlotte, N.C. Stream: FuboTV (free trial) ; Sling ; DirecTV Stream (free trial) Betting: Check out our MA sports betting guide , where you can learn basic terminology, definitions and how to read odds for those interested in learning how to bet in Massachusetts. More College Football What is FuboTV? FuboTV is an internet television service that offers more than 200 channels across sports and entertainment including Paramount+ with SHOWTIME . From the UEFA Champions League to the WNBA to international tournaments ranging across sports, there’s plenty of options available on FuboTV, which offers a free trial, and $20 off the first month for new costumers. What is DirecTV Stream? DirecTV Stream offers practically everything DirecTV provides, except for a remote and a streaming device to connect to your television. Sign up now and get three free months of premium channels including MAX , Paramount+ with SHOWTIME and Starz. What is SlingTV? SlingTV offers a variety of live programing ranging from news and sports and starting as low as $20 a month for your first month. Subscribers also get a month of DVR Plus free if they sign up now. Choose from a variety of sports packages without long-term contracts and with easy cancelation. RELATED CONTENT: ‘Inside the NBA’ will air on ESPN and ABC as part of settlement with NBA By JOE REEDY AP Sports Writer “Inside the NBA” will continue, even though games will no longer be airing on TNT at the end of this season. The popular studio show will appear on ESPN and ABC beginning next season as part of a settlement between Warner Bros. Discovery and the NBA that was announced on Monday. Warner Bros. Discovery, the parent company of TNT Sports, sued the NBA in New York state court in August after the league did not accept the company’s matching offer for one of the packages in its new 11-year media rights deal, which will begin with the 2025-26 season. Even though “Inside the NBA” will be on ESPN and ABC, TNT Sports will continue to produce the show. It will air from Atlanta, except when the show goes on the road. The quartet of Ernie Johnson Jr., Charles Barkley, Kenny Smith and Shaquille O’Neal will remain with the show. Barkley signed an extension with Warner Bros. Discovery in August despite the company losing the NBA. “‘Inside the NBA’ is universally recognized as one of the best and most culturally impactful shows in sports,” ESPN chairman Jimmy Pitaro said. “We have long-admired the immensely talented team and are thrilled to add their chemistry and knowledge to our robust set of NBA studio offerings to super-serve NBA fans like never before. The addition of ‘Inside the NBA’ further solidifies ESPN as the preeminent destination for sports fans.” “Inside the NBA” will handle pregame, halftime and postgame coverage of the NBA Finals on ABC, conference finals and the NBA Playoffs. During the regular season, it will be part of opening week coverage, as well as Christmas Day, all ABC games after Jan. 1, the final week of the season and other marquee events. “The opportunity to continue the iconic and Emmy Award-winning ‘Inside the NBA’ is a huge win for basketball fans everywhere,” NBA Commissioner Adam Silver said in a statement. “We look forward to building on our longstanding partnership with TNT Sports and working together to promote NBA content across key WBD and NBA platforms.” “Inside the NBA” started in 1989, Johnson became the host in 1990 while Smith joined fulltime in 1998. Barkley came aboard in 2000 followed by O’Neal in 2011. The show has garnered 21 Sports Emmy Awards. ESPN will also continue to produce “NBA Countdown” and “NBA Today.” The settlement gives TNT Sports, Bleacher Report and House of Highlights a global license for NBA content with no rights fee for the next 11 years. Warner Bros. Discovery will also continue its relationship with the league’s digital operations, including NBA.com, for five seasons. TNT Sports and the NBA have jointly managed NBA Digital since 2009. Even though TNT Sports will not be airing games in the United States beginning next season, it does have rights to air a full package of games in select countries, including Latin America (excluding Brazil and Mexico), Poland, Denmark, Finland, Norway and Sweden. TNT Sports will also begin showing 13 Big 12 football and 15 men’s basketball games next season as part of a sublicense with ESPN. TNT will air two College Football Playoff games beginning this season also under a sublicense with ESPN. Turner Sports has had an NBA package since 1984 and games have been on TNT since the network launched in 1988. That will end after this season. “Together these agreements ensure fans will continue to enjoy TNT’s ‘Inside the NBA’ and create tremendous value for our entire portfolio as we accelerate the growth of TNT Sports, Bleacher Report, House of Highlights and our global sports business,” Warner Bros. Discovery CEO David Zaslav said in a statement. “We are pleased to partner with the NBA and Disney/ESPN, and to have solidified long-term rights and revenue for WBD.” The Associated Press contributed to this article

Oakhurst, CA -- A pile of dirt outside a Chipotle restaurant has turned into a mountain community phenomenon, sparking joy this holiday season. Nicknamed Mount Chipotle, the holiday-time hill is drawing tourists to Oakhurst at time when some businesses are struggling. "Once you get up there it's just a beautiful view, I mean almost better than Yosemite," said Matthew Simpson, a senior at Yosemite High School. "In all honesty, this was the best thing I've ever done in my life," added Angel Herrera. Mount Chipotle is no easy feat for these first-time visitors. "I did not think it would be this treacherous," explained Yosemite High student Tristan Reden. After reaching the top, the group's reward was spectacular. "You can see Vons, you look over here, you have Chipotle; you have Dollar Tree and Verizon," described Reden. The mountain took on a life of its own after Oakhurst photographer Larry Townsend posted video to the Facebook group, Oakhurst Area. Now, the mountain peak turned phenomenon has gone viral. But not everyone is brimming with delight at the mountain's new fame. The Grinch himself was caught green-handed attempting to steal a Christmas tree atop. Local Judy Zendner creating these free one-of-a-kind ornaments. "Everyone's fought so much over politics, over COVID, so it's just fun," said Zendner. "It's just putting the happiness back in Christmas. Giving Christmas back it's spirit." There's no word yet on how long Mt. Chipotle will stand. In the meantime, locals and tourists will continue to climb the summit and make memories.As the investigation into Sarah's death continues, the community has come together to mourn her loss and celebrate her life. Friends and neighbors remember her as a kind and gentle soul who will be dearly missed. A candlelight vigil is being planned in her memory, serving as a poignant reminder of the importance of community support in times of tragedy.

Google is ramping up its push into smart glasses and augmented reality headgear, taking on rivals Apple and Meta with help from its sophisticated Gemini artificial intelligence. The internet titan on Thursday unveiled an Android XR operating system created in a collaboration with Samsung, which will use it in a device being built in what is called internally "Project Moohan," according to Google. The software is designed to power augmented and virtual reality experiences enhanced with artificial intelligence, XR vice president Shahram Izadi said in a blog post. "With headsets, you can effortlessly switch between being fully immersed in a virtual environment and staying present in the real world," Izadi said. "You can fill the space around you with apps and content, and with Gemini, our AI assistant, you can even have conversations about what you're seeing or control your device." Google this week announced the launch of Gemini 2.0, its most advanced artificial intelligence model to date, as the world's tech giants race to take the lead in the fast-developing technology. CEO Sundar Pichai said the new model would mark what the company calls "a new agentic era" in AI development, with AI models designed to understand and make decisions about the world around you. Android XR infused with Gemini promises to put digital assistants into eyewear, tapping into what users are seeing and hearing. An AI "agent," the latest Silicon Valley trend, is a digital helper that is supposed to sense surroundings, make decisions, and take actions to achieve specific goals. "Gemini can understand your intent, helping you plan, research topics and guide you through tasks," Izadi said. More from this section "Android XR will first launch on headsets that transform how you watch, work and explore." The Android XR release was a preview for developers so they can start building games and other apps for headgear, ideally fun or useful enough to get people to buy the hardware. This is not Google's first foray into smart eyewear. Its first offering, Google Glass, debuted in 2013 only to be treated as an unflattering tech status symbol and met with privacy concerns due to camera capabilities. The market has evolved since then, with Meta investing heavily in a Quest virtual reality headgear line priced for mainstream adoption and Apple hitting the market with pricey Vision Pro "spacial reality" gear. Google plans to soon begin testing prototype Android XR-powered glasses with a small group of users. Google will also adapt popular apps such as YouTube, Photos, Maps, and Google TV for immersive experiences using Android XR, according to Izadi. Gemini AI in glasses will enable tasks like directions and language translations, he added. "It's all within your line of sight, or directly in your ear," Izadi said. gc/dw

Andy Murray joins Djokovic’s coaching teamCBC resurrects plans for live New Year's Eve broadcast specials TORONTO — CBC is restoring its annual live New Year's Eve celebration. A year after the national broadcaster cancelled the 2024 special due to "financial pressures," it says the countdown is back on the TV schedule to mark the dawn of 2025. David Friend, The Canadian Press Dec 12, 2024 11:22 AM Dec 12, 2024 11:35 AM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Programmers at CBC say the national broadcaster will restore its annual live New Year's Eve celebrations headed into 2025 after "financial pressures" pushed it off the schedule last year. People watch fireworks during the New Year's Eve celebrations held at Nathan Phillip square in Toronto just after midnight, Tuesday, Jan. 1, 2019. THE CANADIAN PRESS/Tijana Martin TORONTO — CBC is restoring its annual live New Year's Eve celebration. A year after the national broadcaster cancelled the 2024 special due to "financial pressures," it says the countdown is back on the TV schedule to mark the dawn of 2025. Programming begins Dec. 31 with the one-hour "22 Minutes New Year's Eve Pregame Special," a satirical reflection on the year passed with the cast of the political comedy series "This Hour Has 22 Minutes." It will be followed by "Canada Live! Countdown 2025," a special hosted by news anchor Adrienne Arsenault and singer Jann Arden broadcasting live from Toronto's Harbourfront Centre, and anchor Ian Hanomansing and comedian Ali Hassan at Vancouver's VanDusen Botanical Garden. The coast-to-coast show will feature CBC reporters across the country as they count down to the new year in each of the six time zones. Last year, the CBC replaced its live New Year's programming with a taped Just For Laughs special hosted by comedian Mae Martin. It left Canadian viewers without a homegrown countdown on any of the major networks. This report by The Canadian Press was first published Dec. 12, 2024. David Friend, The Canadian Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More The Mix Nearly half of US teens are online 'constantly,' Pew report finds Dec 12, 2024 2:03 PM Ontario mulls U.S. booze ban as Trump brushes off Ford's threat to cut electricity Dec 12, 2024 2:02 PM B.C. boosts tax incentives to support film and television production Dec 12, 2024 2:02 PM Featured Flyer

Huang Yaqiong, also known as the Queen of Mixed Doubles in badminton, has achieved remarkable success in her career, winning numerous championship titles and accolades. Despite her fame and achievements, she remains humble, grounded, and grateful for the opportunities and experiences that have shaped her journey. Huang's positive attitude and unwavering determination serve as a source of motivation and inspiration for people from all walks of life.Darigabat is under clinical development by Cerevel Therapeutics and currently in Phase II for Seizures. According to GlobalData, Phase II drugs for Seizures have an 82% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Darigabat overview Darigabat (CVL-865) is under development for the treatment of panic disorder and drug-resistant focal onset seizures. It is administered orally as a tablet. The drug candidate specifically targets alpha 2,3 and 5 subunits of GABA-A receptor to overcome the . It was under development for the treatment for chronic low back pain and generalized anxiety disorder. Cerevel Therapeutics overview Cerevel Therapeutics (Cerevel), a subsidiary of AbbVie Inc, is a clinical-stage biopharmaceutical company that develops therapies to treat neuroscience diseases. The company’s product pipeline includes various drug candidates such as emraclidine for the treatment of schizophrenia and Alzheimer’s disease psychosis; and darigabat targets epilepsy and panic disorder; tavapadon for both early and late-stage Parkinson’s disease; and CVL-871 to treat dementia-related apathy. The company is also developing other programs such as CVL-354, PDE4 inhibitor, and M4 Agonist for therapeutic areas of major depressive disorder (MDD), psychiatric, neuroinflammatory disorder and neurological indications. Cerevel is headquartered in Cambridge, Massachusetts, the US. For a complete picture of Darigabat’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

Title: Food Exploration in China: American Guy Evan Kyle Falls in Love with Chinese Cuisine

DENVER, Dec. 12, 2024 (GLOBE NEWSWIRE) -- The U.S. continues to benefit from solid economic growth, low unemployment and moderating inflation. From today’s vantage point, the U.S. economy seems likely to continue on that trajectory into 2025. However, the outlook for the rural economy is more volatile and uncertain. Rural industries are disproportionately exposed to federal policy, and the outcome of the 2024 election cycle promises to bring significant changes in the federal government’s approach to everything from international trade and immigration to energy exploration and rural economic development. According to a comprehensive year-ahead outlook report from CoBank’s Knowledge Exchange , the high level of policy uncertainty facing rural industries adds to their already long list of headwinds and challenges. “The environment we enter in 2025 hasn’t fully defined itself yet, but many of the policies proposed by the incoming administration would likely have a negative impact on U.S. agriculture,” said Rob Fox , director of CoBank’s Knowledge Exchange. “Open access to export markets and labor availability are critically important for agricultural producers and processors. Depending on how policy plays out, those two areas could be big challenges in 2025 and beyond.” The CoBank 2025 outlook report examines several key factors that will shape agriculture and market sectors that serve rural communities throughout the U.S. U.S. Economy: A New Economic Era Begins Most economists are forecasting 2025 U.S. GDP growth around 2.5%-3.0%, essentially the same as today. However, those forecasts are based on rather mild assumptions on forthcoming policy changes. When taken in isolation, President-elect Trump’s proposed policies — tax cuts, decreased labor supply and tariffs on imported goods — are all inflationary. Consequently, longer-term interest rates have already edged higher, and the market has downshifted expectations for further Fed rate cuts in 2025. There is a good chance the proposed tariffs and the crackdown on undocumented immigrants will be more disruptive than markets have priced in, particularly in industries like construction and agriculture. U.S. Government: Trump Administration, Congress Set for Bustling January Start Congress is expected to wrap up the lame duck session of the 118th Congress by Dec. 19, hopefully addressing important pieces of unfinished business. A one-year extension of the 2018 Farm Bill is increasingly likely. President-elect Trump is expected to pursue an ambitious first-100 days of executive orders and other legislative activity that will likely include many of his campaign promises. These may include significant deportation efforts and immigration reform, implementation of tariffs, extending the 2017 tax cuts and providing regulatory relief rolling back the Biden administration’s initiatives. The 119th Congress will have a long and challenging to-do list when members return to Washington on Jan. 3. U.S. Agricultural Economy: Trade War Could Send Ag Economy from Bad to Worse The short-lived commodity boom precipitated by global droughts, the war in Ukraine and COVID-19 supply issues is now a distant memory. Row crop prices are down nearly 50% from their 2022 highs. But production costs have remained elevated, and profitability has plunged to decade-plus lows. The silver lining is that dairy and livestock producers are generally profitable due to low feed costs and resilient consumer demand. However, more headwinds may be coming for both the crop and livestock sectors. President-elect Trump rode to victory on two main economic policy proposals: enact significant import tariffs and reduce immigration while deporting undocumented residents. In theory, these policies could achieve some limited objectives, but it is hard to paint them as anything but negative for the U.S. farm economy. Grains, Farm Supply & Biofuels: Policy Uncertainty Weighs on Exports, Biofuels A strengthening U.S. dollar, combined with the potential for trade disputes and record-large South American crops, weigh heavily on the outlook for grain and oilseed prices in 2025. U.S. farmers are widely expected to struggle with further margin compression as weaker commodity prices test farmers’ ability to lower production costs. Crop input decisions will be evaluated much more closely with a focus on inputs that provide the greatest return on investment. The bearish outlook for oil prices diminishes the demand picture for ethanol, biodiesel and renewable diesel. Uncertainty over U.S. biofuel policy under the new administration also clouds the demand outlook for biofuels. Animal Protein: Rising Margins Improve Prospects for Growth Falling feed costs and rising producer margins have renewed expansion interest in animal protein segments. However, labor, construction and land costs remain elevated, tempering expectations for any meaningful supply growth in the near term. U.S. beef cow herd expansion is not expected to start until 2026 or 2027. The smaller herd will further support higher feeder and fed cattle prices in the coming year. With consumers now pushing back on beef prices already near historic highs, packer margins will remain under pressure well into 2025. Dairy: Record Investment Will Continue to Grow the Category The U.S. will see an unprecedented $8 billion in new dairy processing investment through 2026. Some of the new plants are poised to come online in 2025, with about half of the investment in the cheese category. The expected surge in cheese and whey output will likely put downward pressure on dairy product prices in the second half of the year. Sourcing additional milk supplies to fill new plant capacity is a looming question. 2023 and 2024 will go down as the first back-to-back years since the late 1960s that U.S. milk production took a downturn. On the flip side, higher component levels in farmgate milk, largely butterfat and protein, have lifted finished product yields. Food & Beverage: Health and Nutrition Take Center Stage The headline news for food, beverage and consumer packaged goods in 2025 is President-elect Trump’s nomination of Robert F. Kennedy Jr. to lead the Department of Health and Human Services. Kennedy’s purported goals include eliminating ingredients banned in other countries and “getting the chemicals out” of America’s food supply. Meanwhile, consumers’ renewed focus on their health and the popularity of GLP-1 weight-loss drugs are showing signs of impacting food manufacturers. GLP-1 users purchase around 8% less food compared with average consumers, according to J.P. Morgan research. Food and beverage manufacturers’ concerns about volume attrition are likely to continue well into 2025. Power & Energy: What an IRA Rollback Might Look Like President-elect Trump’s return to the White House will signal a significant shift in U.S. energy policy. While he has promised to end the Inflation Reduction Act, slowing the clean energy momentum that has accelerated under the IRA may be more difficult than imagined. Popular programs in the IRA have directed significant investments to many rural and economically distressed communities. And more than a dozen House Republicans have voiced concern that repealing the IRA could jeopardize ongoing development in their communities. Clawing back IRA funds that have already been allocated could prove to be very difficult. The more likely scenario is that unallocated IRA funding will be redirected to other priorities. Digital Infrastructure: Rural Connectivity Faces New Challenges Political uncertainty and low participation in the Broadband, Equity, Access and Deployment program raises big questions for bridging the digital divide in the year ahead. The $42.5 billion BEAD program, created by the Infrastructure Investment and Jobs Act, includes an unprecedented level of government support. However, a lack of operator participation could blunt the impact of this well-intended program to bring reliable broadband access to underserved rural areas. Many small operators lack the specialized expertise or financial resources to meet some of the complicated BEAD requirements. Read the full report, The Year Ahead: Forces That Will Shape the U.S. Rural Economy in 2025 . About CoBank CoBank is a cooperative bank serving vital industries across rural America. The bank provides loans, leases, export financing and other financial services to agribusinesses and rural power, water and communications providers in all 50 states. The bank also provides wholesale loans and other financial services to affiliated Farm Credit associations serving more than 77,000 farmers, ranchers and other rural borrowers in 23 states around the country. CoBank is a member of the Farm Credit System, a nationwide network of banks and retail lending associations chartered to support the borrowing needs of U.S. agriculture, rural infrastructure and rural communities. Headquartered outside Denver, Colorado, CoBank serves customers from regional banking centers across the U.S. and also maintains an international representative office in Singapore. Corporate Communications CoBank 800-542-8072 news@cobank.com

Looking for a new social media platform because X, Threads and Mastodon just aren’t cutting it? You could try Bluesky. People seeking to avoid chaos, noise and political bluster in the aftermath of the U.S. elections are noticing a different mood on the Bluesky social platform, where the vibe is seemingly welcoming and there are noticeably fewer trolls. The site announced it had rapidly added more than a million new users in the week after Election Day, and has emerged as one of the fastest growing rivals to Elon Musk’s X and similar platforms. If you’re tempted to check out the new space, here’s a guide on how Bluesky works: Maybe you’re not ready to commit to adding yet another social media account. No problem — you can still look around on Bluesky without signing up because all posts and profiles are public. You might get a sense of deja vu, because the platform’s look and feel are very similar to X. That should be no surprise because Twitter co-founder Jack Dorsey was an early Bluesky champion. (Dorsey’s no longer involved with Bluesky, which is owned and run by its executive team as a public benefit corporation.) If you take the plunge and get an account, you’ll need a username. You’ll notice Bluesky handles are a little bit different because they end by default in the site’s domain, .bsky.social. You can personalize your handle to make it more memorable, by using your own website’s domain or buying a custom one through Bluesky. But it might not be something most newbie users need or want to do right away. Bluesky boasts that it gives users “algorithmic choice” to tailor the content they’re shown instead of leaving it up to the whims of a centralized system. “Our online experience doesn’t have to depend on billionaires unilaterally making decisions over what we see,” it says. What it means is that you can follow custom feeds set up by other users, or design your own. If you tap #Feeds in the menu on the left, you’ll see some default offerings like Cat Pics and Gardening. My Bangers is a list of your most popular posts by likes and Catch Up shows the site’s most popular posts from the past 24 hours. You can find more by doing a search and tapping the Feeds button. There’s also the usual “Discover” feed of suggested posts and a chronological feed of accounts that you follow. To help new users settle in, Bluesky has starter packs of recommended feeds and accounts to follow, which anyone can create and share. They don’t show up in Bluesky’s search results but can be found in directories online. Or someone might share one with you. After I signed up, a colleague pointed me to one for major news outlets. There are tens of thousands of starter packs, ranging from broadly appealing topics like Taylor Swift to niche interests like cargo bikes or U.K. comedians. You can follow the whole pack or scroll down the list to choose individual accounts. What about people you followed on X? There’s a browser extension tool called Sky Follower Bridge that will help you find X users who’ve migrated to Bluesky. But check before clicking the follow button to make sure it’s not a different user using the same display name or handle. Ready to join the conversation? You can write posts or reply to others but keep it short because there’s a limit of 300 characters — 20 more than on X. You can also upload photos and videos, though videos can’t be longer than 60 seconds. GIFs and emojis are, of course, available too. You can still @ people by typing in their username, like posts by tapping a heart icon or use hashtags to highlight a theme. Bluesky has added a menu to hashtags, so when you click on one you’ll get different options for seeing, or muting, posts on that topic. Bluesky’s decentralization ethos extends to the content control options it offers. For starters, users can choose in their settings menu whether to see replies, reposts or quote posts in their feed. Specific words or tags can be muted temporarily, or forever, while accounts can be muted or blocked individually, or in bulk by adding them a moderation list. You can even fine tune the level of adult content that shows up in your feed. Bluesky has a team of content moderators to police the site for material that’s illegal or breaks the rules. But it’s also taking a different approach by open-sourcing its content moderation system in an attempt to resolve problems with traditional moderation services which it says “lack transparency and user control.” So, individuals or groups can set up their own content filters, or labelers, that go beyond what Bluesky offers. These labelers can be used to categorize content or users, which can then be blocked or hidden. But they could also be used for informational or creative purposes, like curating or verifying content.

IRVING, Texas , Nov. 26, 2024 /PRNewswire/ -- RumbleOn, Inc. (NASDAQ: RMBL) (the "Company" or "RumbleOn") announced today that it has commenced a $10.0 million fully backstopped registered equity rights offering (the "Rights Offering"), pursuant to which the Company is expected to receive aggregate gross proceeds of $10.0 million , less expenses related to the Rights Offering. The Company intends to use the proceeds from the Rights Offering for general corporate purposes which may include repayment of the Company's convertible senior 6.75% promissory notes due January 1, 2025 . The proceeds raised will also satisfy, in part, the additional capital financing obligations of the Company pursuant to a recent amendment to the Company's credit agreement with Oaktree. The Company is distributing at no charge to the holders of (i) its Class A common stock, par value $0.001 per share (the "Class A common stock"), and (ii) Class B common stock, par value $0.001 per share (the "Class B common stock" and, together with the Class A common stock, the "common stock"), in each case as of the close of business on November 25, 2024 (the "Record Date"), non-transferable subscription rights (the "Subscription Rights") to purchase up to 2,392,344 shares of Class B common stock at price of $4.18 per share (the "Subscription Price"). The aggregate subscription value of all shares of Class B common stock available for purchase in the Rights Offering is $10.0 million . Each holder of common stock as of the Record Date (each, an "Eligible Stockholder") will receive one Subscription Right for each share of the common stock owned as of the Record Date. Each Subscription Right entitles the holder to purchase 0.0677 shares of Class B common stock. The Company will not issue any fractional shares of Class B common stock in the Rights Offering. Instead, the Company will round down the aggregate number of shares of Class B common stock the Eligible Stockholders are entitled to receive to the nearest whole number. Accordingly, as each Subscription Right represents the right to purchase 0.0677 shares of Class B common stock, an Eligible Stockholder must hold at least 15 shares of Class A common stock or Class B common stock to receive sufficient Subscription Rights to purchase at least one share of Class B common stock in the Rights Offering. Eligible Stockholders will not be entitled to exercise an over-subscription privilege to purchase additional shares of Class B common stock that may remain unsubscribed as a result of any unexercised Subscription Rights. The Subscription Rights will expire and will have no value if they are not exercised prior to 5:00 p.m. Eastern Time , on the expiration time for the Rights Offering (the "Expiration Time"), which is currently expected to be 5:00 p.m. Eastern time on December 12, 2024 , unless the Company, in its sole discretion, extends the period for exercising the Subscription Rights. Subject to the terms and conditions of the Support and Standby Purchase Agreement (defined below), the Company reserves the right to cancel, terminate, amend, or extend the Rights Offering at any time prior to the Expiration Time. On November 26 , 2024, the Company entered into a support and standby purchase agreement (the "Support and Standby Purchase Agreement") with Stone House Capital Management, LLC, which is a holder of Class B common stock and is managed by Mark Cohen , a member of the board of directors of the Company (together with its affiliates, the "Standby Purchaser"), and Mark Tkach and William Coulter , each of whom is a holder of the Class B common stock and a member of the board of directors of the Company (collectively, the "Support Purchasers" and, together with the Standby Purchaser, the "Investors"). The Support and Standby Purchase Agreement provides, among other things, that (i) the Standby Purchaser will purchase from the Company in a private placement any shares of Class B common stock included in the Rights Offering that are not subscribed for and purchased by Eligible Stockholders (collectively, the "Backstop Securities") for the same per share Subscription Price payable by the Eligible Stockholders electing to exercise their Subscription Rights in the Rights Offering; and (ii) each Support Purchaser will exercise all of his respective Subscription Rights in full prior to the Expiration Time. Other Important Information The Subscription Rights will not be listed for trading on any stock exchange or market. Therefore, there will be no public market for the Subscription Rights. However, the shares of Class B common stock issued upon the exercise of the Subscription Rights will remain listed on The Nasdaq Capital Market of the Nasdaq Stock Market LLC under the symbol "RMBL." The Company expects that Broadridge Corporate Issuer Solutions, LLC, the subscription and information agent for the Rights Offering, will distribute subscription documents for the Rights Offering to Eligible Stockholders beginning on or about November 26, 2024 . Holders of shares of common stock held in "street name" through a brokerage account, bank or other nominee should contact their broker, bank or other nominee for details regarding participation in the Rights Offering. For any questions or further information about the Rights Offering, please contact the information agent, at (888) 789-8409 (Toll-Free), or via email at shareholder@broadridge.com . Neither the Company nor its board of directors has made or will make any recommendation to holders regarding participation in the Rights Offering. Holders should make an independent investment decision about whether to participate in the Rights Offering based on their own assessment of the Company's business and the Rights Offering. The offering of the Class B common stock pursuant to the Rights Offering is being made pursuant to the Company's existing effective shelf registration statement on Form S-3 (Reg. No. 333-281862) on file with the Securities and Exchange Commission (the "SEC") and a prospectus supplement (and the accompanying base prospectus) filed with the SEC on the date hereof. The information in this press release is not complete and is subject to change. This press release shall not constitute an offer to sell or a solicitation of an offer to buy any securities, nor shall there be any offer, solicitation or sale of the securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful under the securities laws of such state or jurisdiction. The Rights Offering will be made only by means of the prospectus supplement (and the accompanying base prospectus) filed with the SEC on the date hereof. About RumbleOn RumbleOn, Inc. (NASDAQ: RMBL), operates through two operating segments: our Powersports dealership group and Wholesale Express, LLC, an asset-light transportation services provider focused on the automotive industry. Our Powersports group is the largest powersports retail group in the United States (as measured by reported revenue, major unit sales and dealership locations), offering over 500 powersports franchises representing 50 different brands of products. Our Powersports group sells a wide selection of new and pre-owned products, including parts, apparel, accessories, finance & insurance products and services, and aftermarket products. We are the largest purchaser of pre-owned powersports vehicles in the United States and utilize RideNow's Cash Offer to acquire vehicles directly from consumers. For more information on RumbleOn, please visit rumbleon.com . Cautionary Note on Forward-Looking Statements The Company's press release contains statements that constitute "forward-looking statements" within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, those regarding the Company's plans to launch a Rights Offering, the anticipated final terms, timing and completion of the proposed Rights Offering, and the use of proceeds from the proposed Rights Offering. Forward-looking statements generally can be identified by words such as "anticipates," "believes," "continues," "could," "estimates," "expects," "intends," "hopes," "may," "plan," "possible," "potential," "predicts," "projects," "should," "targets," "would" and similar expressions, although not all forward-looking statements contain these identifying words. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from current expectations and beliefs, including, but not limited to, risks and uncertainties related to: whether the proposed transactions will be completed in a timely manner, or at all; the risk that all of the closing conditions for the proposed Rights Offering are not satisfied; the occurrence of any event, change or other circumstance that could cause the Company not to proceed with the Rights Offering; the determination of the final terms of the proposed Rights Offering; the satisfaction of customary closing conditions related to the proposed Rights Offering; risks related to the diversion of management's attention from RumbleOn's ongoing business operations; the impact of general economic, industry or political conditions in the United States or internationally, as well as the other risk factors set forth under the caption "Risk Factors" in the registration statement, as amended, and in RumbleOn's Annual Report for the year ended December 31, 2023 and Quarterly Reports on Form 10-Q for the quarters ended March 30, 2024 , June 30, 2024 and September 30, 2024 and in any other subsequent filings made with the SEC by RumbleOn. There can be no assurance that RumbleOn will be able to complete the proposed Rights Offering on the anticipated terms, or at all. Any forward-looking statements contained in this press release speak only as of the date hereof, and RumbleOn specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. View original content to download multimedia: https://www.prnewswire.com/news-releases/rumbleon-announces-commencement-of-10-0-million-fully-backstopped-registered-rights-offering-302316964.html SOURCE RumbleOnAP News Summary at 11:03 a.m. EST

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